Targeting the IGF-1R: The Tale of the Tortoise and the Hare

doi:10.3389/fendo.2015.00064

Article

Targeting the IGF-1R: The Tale of the Tortoise and the Hare

27 Apr 2015

Abstract excerpt

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development and maintenance of cancer. Since the first links between growth factor receptors and oncogenes were noted over three decades ago, targeting the IGF-1R has been of great interest. This review follows the progress from inception through intense pharmaceutical development, disappointing clinical trials and recent updates to...

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