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Drugging IGF-1R in cancer: New insights and emerging opportunities

23 Mar 2022

Abstract excerpt

The insulin-like growth factor (IGF) axis plays important roles in cancer development and metastasis. The type 1 IGF receptor (IGF-1R) is a key member in the IGF axis and has long been recognized for its oncogenic role in multiple cancer lineages. Here we review the occurrence of IGF-1R aberrations and activation mechanisms in cancers, which justify the development of anti-IGF-1R therapies. We describe the...

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PMID: 37013053
DOI: 10.1016/j.gendis.2022.03.002

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