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Article

Targeting the IGF1 axis in cancer proliferation

10 Aug 2009

Abstract excerpt

The IGF network of ligands, cell-surface receptors and IGF-binding proteins has important roles at multiple levels, including the cellular, organ and organism levels. The IGF system mediates growth, differentiation and developmental processes, and is also involved in various metabolic activities. Dysregulation of IGF system expression and action is linked to diverse pathologies, ranging from growth deficits to...

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Share to Cancer, Hypoxia, and Metabolism
Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 19663648
DOI: 10.1517/14728220903201702

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