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Article

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

3 Jun 2020

Abstract excerpt

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing the rationale for targeting IGF axis in cancer. However, clinical trials of the type I IGF receptor (IGF-IR)-targeted agents have been largely disappointing. Accumulating evidence demonstrates that the IGF...

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PMID: 32493414
DOI: 10.1186/s13045-020-00904-3

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