Article
Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity.
Genetics research - 14 Sept 2015
Rask-Andersen Mathias, Sällman Almén Markus, Jacobsson Josefin A, Ameur Adam, Moschonis George, Dedoussis George, Marcus Claude, Gyllensten Ulf, Fredriksson Robert, Schiöth Helgi B
Abstract excerpt
Genome-wide association studies (GWAS) have revealed association of a locus approximately 25b downstream of the TMEM18 gene with body mass and obesity. We utilized targeted re-sequencing of the body mass associated locus in proximity of TMEM18 in a case-control population of severely obese children and adolescents from the Stockholm area. We expanded our study to include the TMEM18 gene itself, with the aim of...
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