Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

doi:10.1161/CIRCGENETICS.13.000067

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Article

Sequence variation in TMEM18 in association with body mass index: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

Circulation. Cardiovascular genetics - 1 Jun 2014

Liu Ching-Ti, Young Kristin L, Brody Jennifer A, Olden Matthias, Wojczynski Mary K, Heard-Costa Nancy, Li Guo, Morrison Alanna C, Muzny Donna, Gibbs Richard A, Reid Jeffrey G, Shao Yaming, Zhou Yanhua, Boerwinkle Eric, Heiss Gerardo, Wagenknecht Lynne, McKnight Barbara, Borecki Ingrid B, Fox Caroline S, North Kari E, Cupples L Adrienne

Abstract excerpt

BACKGROUND: Genome-wide association studies for body mass index (BMI) previously identified a locus near TMEM18. We conducted targeted sequencing of this region to investigate the role of common, low-frequency, and rare variants influencing BMI. METHODS AND RESULTS: We sequenced TMEM18 and regions downstream of TMEM18 on chromosome 2 in 3976 individuals of European ancestry from 3 community-based cohorts...

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Identifiers

PMID: 24951660
DOI: 10.1161/CIRCGENETICS.13.000067
PMCID: PMC4135723

Genes

TMEM18

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