Article
Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children.
International journal of obesity (2005) - 1 Mar 2013
Sällman Almén M, Rask-Andersen M, Jacobsson J A, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N, Hedberg L A, Ignatovica V, Chrousos G P, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth H B
Abstract excerpt
BACKGROUND: The Fat mass and obesity-associated gene (FTO) was the first gene reliably associated with body mass index in genome-wide association studies on a population level. At present, the genetic variations within the FTO gene are still the common variants that have the largest influence on body mass index. METHODS: In the current study, we amplified the entire FTO gene, in total 412 Kbp, in over 200...
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