Article
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.
BMC medical genetics - 9 Apr 2010
Almén Markus Sällman, Jacobsson Josefin A, Shaik Jafar H A, Olszewski Pawel K, Cedernaes Jonathan, Alsiö Johan, Sreedharan Smitha, Levine Allen S, Fredriksson Robert, Marcus Claude, Schiöth Helgi B
Abstract excerpt
BACKGROUND: TMEM18 is a hypothalamic gene that has recently been linked to obesity and BMI in genome wide association studies. However, the functional properties of TMEM18 are obscure. METHODS: The evolutionary history of TMEM18 was inferred using phylogenetic and bioinformatic methods. The gene'...
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