Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG.

Cell reports - 20 Oct 2020

Landgraf Kathrin, Klöting Nora, Gericke Martin, Maixner Nitzan, Guiu-Jurado Esther, Scholz Markus, Witte A Veronica, Beyer Frauke, Schwartze Julian T, Lacher Martin, Villringer Arno, Kovacs Peter, Rudich Assaf, Blüher Matthias, Kiess Wieland, Körner Antje

Abstract excerpt

TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for most GWAS-derived obesity-susceptibility genes, the functional mechanism remains elusive. We here investigate the relevance of TMEM18 for adipose tissue development and obesity. We demonstrate that adipocyte TMEM18 expression is downregulated in children with obesity. Functionally, downregulation of TMEM18 impairs adipocyte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adipogenesis

Share to Adipose Tissue

Share to Insulin Resistance

Share to Obesity

Share to PPAR gamma

Share to Zebrafish

Source

Identifiers

PMID: 33086065
DOI: 10.1016/j.celrep.2020.108295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG.PMID 33086065Read ↗

The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.Semantic proximity Read ↗

Loss and gain of function experiments implicate TMEM18 as a mediator of the strong association between genetic variants at human Chromosome 2p25.3 and obesitySemantic proximity Read ↗

The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling.Semantic proximity Read ↗

Identifying of immune‐associated genes for assessing the obesity‐associated risk to the offspring in maternal obesity: A bioinformatics and machine learningSemantic proximity Read ↗

The association between polymorphisms near TMEM18 and the risk of obesity: a meta-analysis.Semantic proximity Read ↗

Determination of obesity associated gene variants related to TMEM18 through ultra-deep targeted re-sequencing in a case-control cohort for pediatric obesity.Semantic proximity Read ↗

Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.Semantic proximity Read ↗

miRNAs as cornerstones in adipogenesis and obesitySemantic proximity Read ↗

LncRNA U90926 is dispensable for the development of obesity-associated phenotypes in vivo.Semantic proximity Read ↗

microRNAs in the Regulation of Adipogenesis and ObesitySemantic proximity Read ↗

Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related diseaseSemantic proximity Read ↗

KCTD15 Gene Expression Regulates Adipocyte Differentiation and Is Associated with Obesity in HumansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.