Genetic obesity: next-generation sequencing results of 1230 patients with obesity.

doi:10.1136/jmedgenet-2018-105315

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Article

Genetic obesity: next-generation sequencing results of 1230 patients with obesity.

Journal of medical genetics - 1 Sept 2018

Kleinendorst Lotte, Massink Maarten P G, Cooiman Mellody I, Savas Mesut, van der Baan-Slootweg Olga H, Roelants Roosje J, Janssen Ignace C M, Meijers-Heijboer Hanne J, Knoers Nine V A M, Ploos van Amstel Hans Kristian, van Rossum Elisabeth F C, van den Akker Erica L T, van Haaften Gijs, van der Zwaag Bert, van Haelst Mieke M

Abstract excerpt

BACKGROUND: Obesity is a global and severe health problem. Due to genetic heterogeneity, the identification of genetic defects in patients with obesity can be time consuming and costly. Therefore, we developed a custom diagnostic targeted next-generation sequencing (NGS)-based analysis to simultaneously identify mutations in 52 obesity-related genes. The aim of this study was to assess the diagnostic yield of...

Topics

Adolescent
Adult
Aged
Body Mass Index
Child
Child, Preschool
Female
Genetic Heterogeneity
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Testing

High-Throughput Nucleotide Sequencing

Humans

Infant

Infant, Newborn

Male

Middle Aged

Mutation

Netherlands

Source

Open in PubMed

Identifiers

PMID: 29970488
DOI: 10.1136/jmedgenet-2018-105315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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