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A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes.

Diabetologia - 1 Dec 2015

Arndt Tanja, Wedekind Dirk, Jörns Anne, Tsiavaliaris Georgios, Cuppen Edwin, Hedrich Hans-Jürgen, Lenzen Sigurd

Abstract excerpt

AIMS/HYPOTHESIS: The LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, arose through a spontaneous mutation within the inbred strain LEW.1AR1. A susceptibility locus (Iddm8) on rat chromosome 1 (RNO1) has been identified previously, which is accompanied by autoimmune diabetes and the additional phenotype of a variable CD3(+) T cell frequency. METHODS: In the present study we characterised the Iddm8...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26363782
DOI: 10.1007/s00125-015-3757-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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