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Article

Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2005

Weiss Heike, Bleich Andre, Hedrich Hans-Jürgen, Kölsch Bernd, Elsner Matthias, Jörns Anne, Lenzen Sigurd, Tiedge Markus, Wedekind Dirk

Abstract excerpt

The LEW.1AR1-iddm/Ztm rat is a new animal model of type 1 diabetes mellitus, which shows an autosomal recessive mode of inheritance for the diabetes-inducing gene. The aim of this study was to define predisposing loci of the diabetic syndrome by linkage analysis using microsatellite markers. A backcross population of 218 rats (BN x LEW.1AR1-iddm) x LEW.1AR1-iddm was analyzed using 157 polymorphic microsatellite...

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PMID: 16075370
DOI: 10.1007/s00335-004-3022-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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