Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.

doi:10.1016/s0896-8411(02)00111-7

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Article

Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.

Journal of autoimmunity - 1 Mar 2003

Klöting Ingrid, van den Brandt Jens, Klöting Nora, Radović Branislav

Abstract excerpt

Diabetes in the biobreeding (BB) rat results from autoimmune destruction of pancreatic beta cells and thereby it is sharing many features with human type 1 diabetes. Independent crossing studies have demonstrated that diabetes in the BB rat is explained by at least three recessively acting genes termed Iddm1 (major histocompatibility complex), Iddm2 (lymphopenia), Iddm3 (unknown). About 50% of Iddm1 and Iddm2...

Topics

Animals
Crosses, Genetic
Diabetes Mellitus, Type 1
Female
Genes, Recessive
Genetic Predisposition to Disease
Male
Rats
Rats, Inbred BB
Rats, Inbred BN

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Identifiers

PMID: 12657525
DOI: 10.1016/s0896-8411(02)00111-7

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