Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.

doi:10.1186/1471-2156-6-9

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Article

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.

BMC genetics - 18 Feb 2005

Maier Lisa M, Smyth Deborah J, Vella Adrian, Payne Felicity, Cooper Jason D, Pask Rebecca, Lowe Christopher, Hulme John, Smink Luc J, Fraser Heather, Moule Carolyn, Hunter Kara M, Chamberlain Giselle, Walker Neil, Nutland Sarah, Undlien Dag E, Rønningen Kjersti S, Guja Cristian, Ionescu-Tîrgoviste Constantin, Savage David A, Strachan David P, Peterson Laurence B, Todd John A, Wicker Linda S, Twells Rebecca C

Abstract excerpt

BACKGROUND: One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 diabetes. Linkage and congenic strain analyses have identified several NOD mouse Idd (insulin dependent diabetes) loci, which have been mapped to small chromosome intervals, for...

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PMID: 15720714
DOI: 10.1186/1471-2156-6-9
PMCID: PMC551616

Genes

TNFRSF9
VAV3

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