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Article

Nevospheres from neurocutaneous melanocytosis cells show reduced viability when treated with specific inhibitors of NRAS signaling pathway.

Neuro-oncology - 1 Apr 2016

Basu Dipanjan, Salgado Cláudia M, Bauer Bruce S, Johnson Donald, Rundell Veronica, Nikiforova Marina, Khakoo Yasmin, Gunwaldt Lorelei J, Panigrahy Ashok, Reyes-Múgica Miguel

Abstract excerpt

BACKGROUND: Neurocutaneous melanocytosis (NCM) is characterized by clonal nevomelanocytic proliferations in the CNS and skin. Given the scarcity of effective therapeutic targets, testing new drugs requires a reliable and reproducible in vitro cellular model of the disease. METHODS: We generated nevomelanocytic spheroids in vitro from lesions of the spinal cord, brain, and skin from 4 NCM patients. Nevomelanocytic...

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Identifiers

PMID: 26354928
DOI: 10.1093/neuonc/nov184
PMCID: PMC4799680

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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