Article
Druggable targets in pediatric neurocutaneous melanocytosis: Molecular and drug sensitivity studies in xenograft and ex vivo tumor cell culture to identify agents for therapy.
Neuro-oncology - 1 Jun 2015
Ruan Yibing, Kovalchuk Anna, Jayanthan Aarthi, Lun Xueqing, Nagashima Yoji, Kovalchuk Olga, Wright James R, Pinto Alfredo, Kirton Adam, Anderson Ronald, Narendran Aru
Abstract excerpt
BACKGROUND: Neurocutaneous melanocytosis (NCM) is a rare congenital disorder that presents with pigmented cell lesions of the brain or leptomeninges in children with large or multiple congenital melanocytic nevi. Although the exact pathological processes involved are currently unclear, NCM appears to arise from an abnormal development of melanoblasts or melanocyte precursors. Currently, it has an extremely poor...
Topics
- Animals
- Antineoplastic Agents
- Child, Preschool
- GTP Phosphohydrolases
- Heterografts
- Humans
- Male
- Melanosis
- Membrane Proteins
- Mice
- Mice, Nude
- Mutation
- Neurocutaneous Syndromes