Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor.

Acta neuropathologica communications - 8 Apr 2014

Küsters-Vandevelde Heidi Vn, Willemsen Annelieke Ecab, Groenen Patricia Jta, Küsters Benno, Lammens Martin, Wesseling Pieter, Djafarihamedani Melika, Rijntjes Jos, Delye Hans, Willemsen Michel A, van Herpen Carla Ml, Blokx Willeke Am

Abstract excerpt

Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the association of large and/or multiple congenital melanocytic nevi (CMN) of the skin with melanocytic lesions of the leptomeninges, including melanocytosis. Leptomeningeal melanocytosis carries a poor prognosis once neurological symptoms develop. Despite surgery, which is often not radical, few other treatment options exist. Recently,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzimidazoles
Share to Brain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to GTP Phosphohydrolases

Share to Magnetic Resonance Imaging

Share to Melanosis

Share to Neurocutaneous Syndromes

Share to Spinal Cord

Source

Open in PubMed Open full text

Identifiers

PMID: 24713450
DOI: 10.1186/2051-5960-2-41
PMCID: PMC4023633

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor.PMID 24713450Read ↗

Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.Semantic proximity Read ↗

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.Semantic proximity Read ↗

Druggable targets in pediatric neurocutaneous melanocytosis: Molecular and drug sensitivity studies in xenograft and ex vivo tumor cell culture to identify agents for therapy.Semantic proximity Read ↗

NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis.Semantic proximity Read ↗

Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.Semantic proximity Read ↗

Amplification of mutated NRAS leading to congenital melanoma in neurocutaneous melanocytosis.Semantic proximity Read ↗

Congenital melanocytic nevi: update in genetics and management.Semantic proximity Read ↗

[An update on molecular pathology of melanocytic nerve and melanoma].Semantic proximity Read ↗

An update on congenital melanocytic nevus syndrome: A case report and literature review.Semantic proximity Read ↗

Melanoma in congenital melanocytic naevi.Semantic proximity Read ↗

Translating current basic research into future therapies for neurofibromatosis type 1.Semantic proximity Read ↗

GNAQQ209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.