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Article

Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem-cell phenotype.

The British journal of dermatology - 1 Aug 2013

Kinsler V A, Anderson G, Latimer B, Natarajan D, Healy E, Moore G E, Sebire N J

Abstract excerpt

BACKGROUND: Multiple congenital melanocytic naevi (CMN) in one individual are caused by somatic mosaicism for NRAS mutations; however, the lineage of the mutated cells remains uncertain. OBJECTIVES: To test the hypothesis that CMN may be derived from cutaneous stem cells. METHODS: Sixty-six CMN samples from 44 patients were stained for immunohistochemical (IHC) markers of melanocytic differentiation (TYR, TRP1,...

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Topics

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Share to Antigens, Differentiation
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Microscopy, Electron, Transmission

Share to Neoplastic Stem Cells

Share to Nevus, Pigmented

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Source

Open in PubMed Open full text

Identifiers

PMID: 23517330
DOI: 10.1111/bjd.12323
PMCID: PMC3838625

Genes

MITF
MTOR
NRAS
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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