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Article

Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction.

Signal transduction and targeted therapy - 16 May 2025

Wei Boxuan, Yu Qingxiong, Jin Jiamin, Zhu Danli, Lai Bohan, Gu Jieyu, Yang Ran, Huang Huailiang, Lin Hongzhan, Zhang Liang, Zan Tao, Xie Feng, Zhang Kang, Li Qingfeng

Abstract excerpt

Giant congenital melanocytic nevus (GCMN) is a RAS/RAF mutation-driven syndrome characterized by extensive melanocytic lesions, posing psychological challenges and a lifelong risk of malignancy. Existing treatments like surgical resection and laser therapy fail to fully remove lesions, and MAPK inhibitors show limited efficacy. This study identified a predominant population of senescent cells and a minority of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40374605
DOI: 10.1038/s41392-025-02247-2
PMCID: PMC12081681

Genes

BCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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