Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.

Journal of pediatric hematology/oncology - 1 Mar 2021

Mitre Victoria, Heym Kenneth, Clark Gary D, Venkatramani Rajkumar

Abstract excerpt

Neurocutaneous melanocytosis (NCM) is a disorder characterized by multiple or large congenital nevi and excessive proliferation of melanocytes in the leptomeninges and brain parenchyma. The majority of NCM is a result of somatic mosaicism due to a single postzygotic mutation in codon 61 of NRAS. Patients with NCM are at high risk of developing leptomeningeal melanoma. The prognosis for leptomeningeal melanoma is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Infant, Newborn

Share to Melanoma

Share to Melanosis

Share to Meningeal Neoplasms

Share to Neurocutaneous Syndromes

Source

Identifiers

PMID: 31764519
DOI: 10.1097/MPH.0000000000001680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.PMID 31764519Read ↗

Congenital melanocytic nevi: update in genetics and management.Semantic proximity Read ↗

NRASQ61K mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis.Semantic proximity Read ↗

An update on congenital melanocytic nevus syndrome: A case report and literature review.Semantic proximity Read ↗

Melanoma in congenital melanocytic naevi.Semantic proximity Read ↗

Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.Semantic proximity Read ↗

Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor.Semantic proximity Read ↗

Druggable targets in pediatric neurocutaneous melanocytosis: Molecular and drug sensitivity studies in xenograft and ex vivo tumor cell culture to identify agents for therapy.Semantic proximity Read ↗

Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.Semantic proximity Read ↗

Amplification of mutated NRAS leading to congenital melanoma in neurocutaneous melanocytosis.Semantic proximity Read ↗

Acquisition of Somatic NRAS Mutations in Central Nervous System Melanocytes: A Predisposing Risk Factor to Primary Melanoma of the Central Nervous System, a Frequently Forgotten Pitfall in Congenital Nevi.Semantic proximity Read ↗

NRAS(Q61K) mutated primary leptomeningeal melanoma in a child: case presentation and discussion on clinical and diagnostic implications.Semantic proximity Read ↗

BRAF mutations are also associated with neurocutaneous melanocytosis and large/giant congenital melanocytic nevi.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.