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Article

Clonogenic cell subpopulations maintain congenital melanocytic nevi.

The Journal of investigative dermatology - 1 Mar 2015

Charbel Christelle, Fontaine Romain H, Kadlub Natacha, Coulomb-L'Hermine Aurore, Rouillé Thomas, How-Kit Alexandre, Moguelet Philippe, Tost Jorg, Picard Arnaud, Aractingi Selim, Guégan Sarah

Abstract excerpt

Large congenital melanocytic nevi (lCMN) are benign melanocytic tumors associated with an increased risk of melanoma transformation. They result predominantly from a post-zygotic somatic NRAS mutation. These lesions persist and even increase after birth proportionally to the child's growth. There...

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Source

Identifiers

PMID: 25310409
DOI: 10.1038/jid.2014.437

Genes

NRAS
ABCB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25310409-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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