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Article

Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects.

Carcinogenesis - 1 Nov 2015

Vodicka Pavel, Musak Ludovit, Frank Christoph, Kazimirova Alena, Vymetalkova Veronika, Barancokova Magdalena, Smolkova Bozena, Dzupinkova Zuzana, Jiraskova Katerina, Vodenkova Sona, Kroupa Michal, Osina Oto, Naccarati Alessio, Palitti Fabrizio, Försti Asta, Dusinska Maria, Vodickova Ludmila, Hemminki Kari

Abstract excerpt

Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual differences in its capacity are probably due to corresponding genetic variations. We...

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PMID: 26354780
DOI: 10.1093/carcin/bgv127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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