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Article

Genetic variation in the major mitotic checkpoint genes associated with chromosomal aberrations in healthy humans.

Cancer letters - 1 Oct 2016

Försti Asta, Frank Christoph, Smolkova Bozena, Kazimirova Alena, Barancokova Magdalena, Vymetalkova Veronika, Kroupa Michal, Naccarati Alessio, Vodickova Ludmila, Buchancova Janka, Dusinska Maria, Musak Ludovit, Vodicka Pavel, Hemminki Kari

Abstract excerpt

Non-specific chromosomal aberrations (CAs) are microscopically detected in about 1% of lymphocytes drawn from healthy persons. Causes of CAs in general population are not known but they may be related to risk of cancer. In view of the importance of the mitotic checkpoint machinery on maintaining chromosomal integrity we selected 9 variants in main checkpoint related genes (BUB1B, BUB3, MAD2L1, CENPF,...

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Source

Identifiers

PMID: 27424524
DOI: 10.1016/j.canlet.2016.07.011

Genes

PTTG1
ZWILCH
ZWINT
BUB3
CENPF
ESPL1
NEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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