Article
Chromosomal damage and polymorphisms of DNA repair genes XRCC1 and XRCC3 in workers exposed to cytostatics.
Neuro endocrinology letters - 1 Dec 2006
Musák L'udovít, Vodicka Pavel, Klimentová Gabriela, Soucek Pavel, Hánová Monika, Mikulková Renáta, Buchancová Janka, Vodicková Ludmila, Poláková Veronika, Péc Martin
Abstract excerpt
OBJECTIVES: Medical workers in oncological units have chronically been exposed to low doses of cytostatics (C) with potential consequences on DNA and chromosomal integrity. Our study addresses relationships between chromosomal aberrations (CAs), chromosome (CSA), and chromatid (CTA) types and polymorphisms in DNA repair genes XRCC1 and XRCC3. METHODS: The study was conducted on 72 exposed individuals from...
Topics
- Adult
- Antineoplastic Agents
- Chromosomes, Human
- DNA Damage
- DNA-Binding Proteins
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Medical Staff, Hospital
- Middle Aged
- Occupational Diseases