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Is there evidence of involvement of DNA repair polymorphisms in human cancer?

Mutation research - 1 Aug 2012

Ricceri Fulvio, Matullo Giuseppe, Vineis Paolo

Abstract excerpt

DNA suffers from a wide range of damage, both from extracellular agents and via endogenous mechanisms. Damage of DNA can lead to cancer and other diseases. Therefore, it is plausible that sequence variants in DNA repair genes are involved in cancer development. A recent systematic review and meta-analysis, based on the "Venice criteria", showed that out of 241 associations investigated, only three resulted to...

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PMID: 21864546
DOI: 10.1016/j.mrfmmm.2011.07.013

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ERCC2
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