Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study.

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Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2003

Matullo Giuseppe, Peluso Marco, Polidoro Silvia, Guarrera Simonetta, Munnia Armelle, Krogh Vittorio, Masala Giovanna, Berrino Franco, Panico Salvatore, Tumino Rosario, Vineis Paolo, Palli Domenico

Abstract excerpt

Inherited single nucleotide polymorphisms (SNPs) of DNA repair genes may contribute to variations in DNA repair capacity and susceptibility to cancer. We investigated the role of SNPs in three DNA repair genes (X-ray repair cross-complementing group 1-Arg399Gln, exon 10; X-ray repair cross-complementing group 3-Thr241Met, exon 7; and xeroderma pigmentosum-D-Lys751Gln, exon 23) and their combination, in modulating...

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PMID: 12869411

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