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Article

Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia.

The pharmacogenomics journal - 1 Nov 2016

Krajinovic M, Elbared J, Drouin S, Bertout L, Rezgui A, Ansari M, Raboisson M-J, Lipshultz S E, Silverman L B, Sallan S E, Neuberg D S, Kutok J L, Laverdière C, Sinnett D, Andelfinger G

Abstract excerpt

Anthracyclines are efficient chemotherapy agents. However, their use is limited by anthracycline-induced cardiotoxicity (CT). We investigated the influence of polymorphisms in doxorubicin metabolic and functional pathways on late-onset CT as estimated by echocardiography in 251 childhood acute lymphoblastic leukemia (cALL) patients. Association analyses revealed a modulating effect of two variants: A-1629 T in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26345518
DOI: 10.1038/tpj.2015.63

Genes

ABCC5
NOS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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