Article
Genetic factors in treatment-related cardiovascular complications in survivors of childhood acute lymphoblastic leukemia.
Pharmacogenomics - 1 Sept 2021
Petrykey Kateryna, Rezgui Aziz M, Guern Mathilde Le, Beaulieu Patrick, St-Onge Pascal, Drouin Simon, Bertout Laurence, Wang Fan, Baedke Jessica L, Yasui Yutaka, Hudson Melissa M, Raboisson Marie-Josée, Laverdière Caroline, Sinnett Daniel, Andelfinger Gregor U, Krajinovic Maja
Abstract excerpt
Aim: Cardiovascular disease represents one of the main causes of secondary morbidity and mortality in patients with childhood cancer. Patients & methods: To further address this issue, we analyzed cardiovascular complications in relation to common and rare genetic variants derived through whole-exome sequencing from childhood acute lymphoblastic leukemia survivors (PETALE cohort). Results: Significant...
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