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Article

Possible roles of genetic variations in chemotherapy related cardiotoxicity in pediatric acute lymphoblastic leukemia and osteosarcoma.

BMC cancer - 3 Jul 2018

Sági Judit C, Egyed Bálint, Kelemen Andrea, Kutszegi Nóra, Hegyi Márta, Gézsi András, Herlitschke Martina Ayaka, Rzepiel Andrea, Fodor Lili E, Ottóffy Gábor, Kovács Gábor T, Erdélyi Dániel J, Szalai Csaba, Semsei Ágnes F

Abstract excerpt

BACKGROUND: The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse effects of chemotherapy. One of these is cardiotoxicity which may lead to progressive heart failure in the long term. Cardiotoxicity is contributed mainly to the use of anthracyclines and might have...

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Share to Anthracyclines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Cytochrome P-450 CYP3A

Share to Multidrug Resistance-Associated Protein 2

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Source

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Identifiers

PMID: 29970035
DOI: 10.1186/s12885-018-4629-6
PMCID: PMC6029426

Genes

ABCC2
NQO1

Provenance

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