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Article

Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2012

Visscher Henk, Ross Colin J D, Rassekh S Rod, Barhdadi Amina, Dubé Marie-Pierre, Al-Saloos Hesham, Sandor George S, Caron Huib N, van Dalen Elvira C, Kremer Leontien C, van der Pal Helena J, Brown Andrew M K, Rogers Paul C, Phillips Michael S, Rieder Michael J, Carleton Bruce C, Hayden Michael R

Abstract excerpt

PURPOSE: Anthracycline-induced cardiotoxicity (ACT) is a serious adverse drug reaction limiting anthracycline use and causing substantial morbidity and mortality. Our aim was to identify genetic variants associated with ACT in patients treated for childhood cancer. PATIENTS AND METHODS: We carried out a study of 2,977 single-nucleotide polymorphisms (SNPs) in 220 key drug biotransformation genes in a discovery...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21900104
DOI: 10.1200/JCO.2010.34.3467

Genes

ABCB1
ABCB4
ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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