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Article

Exome array analysis identifies GPR35 as a novel susceptibility gene for anthracycline-induced cardiotoxicity in childhood cancer.

Pharmacogenetics and genomics - 1 Dec 2017

Ruiz-Pinto Sara, Pita Guillermo, Patiño-García Ana, Alonso Javier, Pérez-Martínez Antonio, Cartón Antonio J, Gutiérrez-Larraya Federico, Alonso María R, Barnes Daniel R, Dennis Joe, Michailidou Kyriaki, Gómez-Santos Carmen, Thompson Deborah J, Easton Douglas F, Benítez Javier, González-Neira Anna

Abstract excerpt

OBJECTIVES: Pediatric cancer survivors are a steadily growing population; however, chronic anthracycline-induced cardiotoxicity (AIC) is a serious long-term complication leading to considerable morbidity. We aimed to identify new genes and low-frequency variants influencing the susceptibility to AIC for pediatric cancer patients. PATIENTS AND METHODS: We studied the association of variants on the Illumina...

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Source

Identifiers

PMID: 28961156
DOI: 10.1097/FPC.0000000000000309

Genes

GPR35

Variants

rs12468485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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