Article
Genetic factors in anthracycline-induced cardiotoxicity in patients treated for pediatric cancer.
Expert opinion on drug metabolism & toxicology - 1 Oct 2020
Petrykey Kateryna, Andelfinger Gregor U, Laverdière Caroline, Sinnett Daniel, Krajinovic Maja
Abstract excerpt
INTRODUCTION: Cardiovascular diseases are the main cause of treatment-related morbidity and mortality in childhood cancer patients. Anthracyclines, one of the most common chemotherapeutic agents in treatment regimens, are implicated in chemotherapy-induced cardiotoxicity. AREAS COVERED: This review describes the pharmacogenomic markers related to anthracycline-induced cardiotoxicity affecting childhood cancer...
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