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Article

Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors.

Scientific reports - 29 Aug 2017

Hildebrandt Michelle A T, Reyes Monica, Wu Xifeng, Pu Xia, Thompson Kara A, Ma Jianzhong, Landstrom Andrew P, Morrison Alanna C, Ater Joann L

Abstract excerpt

Anthracycline-based chemotherapy is associated with dose-dependent, irreversible damage to the heart. Childhood cancer survivors with hypertension after anthracycline exposure are at increased risk of cardiotoxicity, leading to the hypothesis that genetic susceptibility loci for hypertension may serve as predictors for development of late cardiotoxicity. Therefore, we determined the association between 12...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28851949
DOI: 10.1038/s41598-017-09517-2
PMCID: PMC5575079

Genes

PLCE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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