Article
Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.
The Journal of biological chemistry - 16 Nov 2001
Shakkottai V G, Regaya I, Wulff H, Fajloun Z, Tomita H, Fathallah M, Cahalan M D, Gargus J J, Sabatier J M, Chandy K G
Abstract excerpt
Apamin-sensitive small conductance calcium-activated potassium channels (SKCa1-3) mediate the slow afterhyperpolarization in neurons, but the molecular identity of the channel has not been defined because of the lack of specific inhibitors. Here we describe the structure-based design of a selective inhibitor of SKCa2. Leiurotoxin I (Lei) and PO5, peptide toxins that share the RXCQ motif, potently blocked human...
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