Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.

doi:10.3390/toxins6072177

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Article

Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.

Toxins - 23 Jul 2014

Luo Ji, Zhang Yiya, Gong Mengting, Lu Shanshan, Ma Yifeng, Zeng Xiongzhi, Liang Songping

Abstract excerpt

Voltage-gated sodium channels (VGSCs; NaV1.1-NaV1.9) have been proven to be critical in controlling the function of excitable cells, and human genetic evidence shows that aberrant function of these channels causes channelopathies, including epilepsy, arrhythmia, paralytic myotonia, and pain. The...

Topics

Animals
HEK293 Cells
Humans
Mutation
NAV1.4 Voltage-Gated Sodium Channel
Patch-Clamp Techniques
Peptides
Rats
Spider Venoms
Transfection
Voltage-Gated Sodium Channel Blockers

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