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Article

Molecular surface of JZTX-V (β-Theraphotoxin-Cj2a) interacting with voltage-gated sodium channel subtype NaV1.4.

Toxins - 23 Jul 2014

Luo Ji, Zhang Yiya, Gong Mengting, Lu Shanshan, Ma Yifeng, Zeng Xiongzhi, Liang Songping

Abstract excerpt

Voltage-gated sodium channels (VGSCs; NaV1.1-NaV1.9) have been proven to be critical in controlling the function of excitable cells, and human genetic evidence shows that aberrant function of these channels causes channelopathies, including epilepsy, arrhythmia, paralytic myotonia, and pain. The effects of peptide toxins, especially those isolated from spider venom, have shed light on the structure-function...

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Identifiers

PMID: 25055801
DOI: 10.3390/toxins6072177
PMCID: PMC4113750

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Source receipt: pubmed, retrieved 7 Sept 2026.

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