Article
Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ.
The Journal of biological chemistry - 25 Mar 2016
Green Brad R, Gajewiak Joanna, Chhabra Sandeep, Skalicky Jack J, Zhang Min-Min, Rivier Jean E, Bulaj Grzegorz, Olivera Baldomero M, Yoshikami Doju, Norton Raymond S
Abstract excerpt
Cone snail toxins are well known blockers of voltage-gated sodium channels, a property that is of broad interest in biology and therapeutically in treating neuropathic pain and neurological disorders. Although most conotoxin channel blockers function by direct binding to a channel and disrupting its normal ion movement, conotoxin μO§-GVIIJ channel blocking is unique, using both favorable binding interactions with...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Conotoxins
- Crystallography, X-Ray
- Disulfides
- Gene Expression
- Models, Molecular
- Molecular Sequence Data
- Muscle Proteins