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Article

Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule.

Channels (Austin, Tex.) - 1 Jan 2000

Choudhary Gaurav, Aliste Marcela P, Tieleman D Peter, French Robert J, Dudley Samuel C

Abstract excerpt

mu-Conotoxin GIIIA (mu-CTX) is a high-affinity ligand for the outer vestibule of selected isoforms of the voltage-gated Na(+) channel. The detailed bases for the toxin's high affinity binding and isoform selectivity are unclear. The outer vestibule is lined by four pore-forming (P) loops, each with an acidic residue near the mouth of the vestibule. mu-CTX has seven positively charged residues that may interact...

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Identifiers

PMID: 18690041
DOI: 10.4161/chan.5112
PMCID: PMC3212855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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