Article
A mutant of the Buthus martensii Karsch antitumor-analgesic peptide exhibits reduced inhibition to hNav1.4 and hNav1.5 channels while retaining analgesic activity.
The Journal of biological chemistry - 3 Nov 2017
Xu Yijia, Meng Xiangxue, Hou Xue, Sun Jianfang, Kong Xiaohua, Sun Yuqi, Liu Zeyu, Ma Yuanyuan, Niu Ye, Song Yongbo, Cui Yong, Zhao Mingyi, Zhang Jinghai
Abstract excerpt
Scorpion toxins can kill other animals by inducing paralysis and arrhythmia, which limits the potential applications of these agents in the clinical management of diseases. Antitumor-analgesic peptide (AGAP), purified from Buthus martensii Karsch, has been proved to possess analgesic and antitumor activities. Trp38, a conserved aromatic residue of AGAP, might play an important role in mediating AGAP activities...
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