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Article

Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development.

Molecules (Basel, Switzerland) - 27 Oct 2017

Brazzolotto Xavier, Igert Alexandre, Guillon Virginia, Santoni Gianluca, Nachon Florian

Abstract excerpt

Human butyrylcholinesterase is a performant stoichiometric bioscavenger of organophosphorous nerve agents. It is either isolated from outdated plasma or functionally expressed in eukaryotic systems. Here, we report the production of active human butyrylcholinesterase in a prokaryotic system after optimization of the primary sequence through the Protein Repair One Stop Shop process, a structure- and sequence-based...

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Identifiers

PMID: 29077024
DOI: 10.3390/molecules22111828
PMCID: PMC6150354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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