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Article

Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent.

Biochemical and biophysical research communications - 4 Jul 2014

Jeong Young-Su, Choi Jung Min, Kyeong Hyun-Ho, Choi Jae-Youl, Kim Eui-Joong, Kim Hak-Sung

Abstract excerpt

V-type nerve agents, known as VX, are organophosphate (OP) compounds, and show extremely toxic effects on human and animals by causing cholinergic overstimulation of synapses. The bacterial organophosphorus hydrolase (OPH) has attracted much attention for detoxifying V-type agents through hydrolysis of the P-S bond. However, low catalytic efficiency of OPH has limited the practical use of the enzyme. Here we...

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PMID: 24824182
DOI: 10.1016/j.bbrc.2014.04.155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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