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Article

The mycotoxin alternariol induces DNA damage and modify macrophage phenotype and inflammatory responses.

Toxicology letters - 19 Nov 2015

Solhaug A, Wisbech C, Christoffersen T E, Hult L O, Lea T, Eriksen G S, Holme J A

Abstract excerpt

Alternariol (AOH), a mycotoxin produced by Alternaria fungi, is frequently found as a contaminant in fruit and grain products. Here we examined if AOH could modify macrophage phenotype and inflammatory responses. In RAW 264.7 mouse macrophages AOH changed the cell morphology of from round to star-shaped cells, with increased levels of CD83, CD86, CD11b, MHCII and endocytic activity. TNFα and IL-6 were enhanced at...

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Identifiers

PMID: 26341179
DOI: 10.1016/j.toxlet.2015.08.1107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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