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The p,p'-DDE disturbs the M1 function without affecting the M2 phenotype nor unstimulated bone marrow-derived macrophages from BALB/c mice.

Toxicology - 1 Jul 2023

Cortés-Montoya Vanessa, Ortiz-Robles Christian D, Rivera-Maya Omar B, Palacios-Valladares José R, Ramirez-Gutierrez Erick F, Calderón-Aranda Emma S

Abstract excerpt

DDT, a persistent organic pollutant, remains affecting human health worldwide. DDT and its most persistent metabolite (p,p'-DDE) negatively affect the immune response regulation and mechanisms involved in protecting against pathogens Such metabolite decreases the capability to limit intracellular growth of Mycobacterium microti and yeast. However, the effect on unstimulated (M0) and anti-inflammatory macrophages...

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PMID: 37236336
DOI: 10.1016/j.tox.2023.153554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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