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Article

Decitabine Promotes Modulation in Phenotype and Function of Monocytes and Macrophages That Drive Immune Response Regulation.

Cells - 12 Apr 2021

Zambuzi Fabiana Albani, Cardoso-Silva Priscilla Mariane, Castro Ricardo Cardoso, Fontanari Caroline, Emery Flavio da Silva, Frantz Fabiani Gai

Abstract excerpt

Decitabine is an approved hypomethylating agent used for treating hematological malignancies. Although decitabine targets altered cells, epidrugs can trigger immunomodulatory effects, reinforcing the hypothesis of immunoregulation in treated patients. We therefore aimed to evaluate the impact of decitabine treatment on the phenotype and functions of monocytes and macrophages, which are pivotal cells of the innate...

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Identifiers

PMID: 33921194
DOI: 10.3390/cells10040868
PMCID: PMC8069756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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