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Article

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

13 Feb 2014

Abstract excerpt

Alveolar macrophage (AM) responses are commonly induced in inhalation toxicology studies, typically being observed as an increase in number or a vacuolated 'foamy' morphology. Discriminating between adaptive AM responses and adverse events during nonclinical and clinical development is a major scientific challenge. When measuring and interpreting induced AM responses, an understanding of macrophage biology is...

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PMID: 24530633
DOI: 10.1016/j.addr.2014.02.001

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