Article
Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype.
PloS one - 5 Jan 2011
Bhatia Shikha, Fei Mingjian, Yarlagadda Manohar, Qi Zengbiao, Akira Shizuo, Saijo Shinobu, Iwakura Yoichiro, van Rooijen Nico, Gibson Gregory A, St Croix Claudette M, Ray Anuradha, Ray Prabir
Abstract excerpt
The ubiquitous fungus Aspergillus fumigatus is associated with chronic diseases such as invasive pulmonary aspergillosis in immunosuppressed patients and allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis or severe asthma. Because of constant exposure to this fungus, it is critical for the host to exercise an immediate and decisive immune response to clear fungal spores to ward off...
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