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Article

Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2015

Mook-Kanamori B B, Valls Serón M, Geldhoff M, Havik S R, van der Ende A, Baas F, van der Poll T, Meijers J C M, P Morgan B, Brouwer M C, van de Beek D

Abstract excerpt

BACKGROUND: Mortality and morbidity in patients with bacterial meningitis result from the proinflammatory response and dysregulation of coagulation and fibrinolysis. Thrombin-activatable fibrinolysis inhibitor (TAFI) is activated by free thrombin or thrombin in complex with thrombomodulin, and plays an antifibrinolytic role during fibrin clot degradation, but also has an anti-inflammatory role by inactivating...

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Share to Carboxypeptidase B2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Community-Acquired Infections

Share to Complement C3b

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Share to Meningitis, Meningococcal

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Source

Identifiers

PMID: 26340319
DOI: 10.1111/jth.13132

Genes

CPB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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