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Article

A functional single nucleotide polymorphism in the thrombin-activatable fibrinolysis inhibitor (TAFI) gene associates with outcome of meningococcal disease.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2004

Kremer Hovinga J A, Franco R F, Zago M A, Ten Cate Hugo, Westendorp R G J, Reitsma P H

Abstract excerpt

In meningococcal sepsis, disseminated intravascular coagulation with deposition of fibrin and formation of microthrombi occurs in various organs and enhanced inhibition of fibrinolysis is associated with adverse outcome. Recently, TAFI (thrombin-activatable fibrinolysis inhibitor) was identified as a link between coagulation and fibrinolysis, as TAFI can be activated by thrombin and once activated potently...

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PMID: 14717966
DOI: 10.1111/j.1538-7836.2004.00557.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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