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Article

Complement factor H contributes to mortality in humans and mice with bacterial meningitis.

Journal of neuroinflammation - 28 Dec 2019

Kasanmoentalib E Soemirien, Valls Serón Mercedes, Engelen-Lee Joo Yeon, Tanck Michael W, Pouw Richard B, van Mierlo Gerard, Wouters Diana, Pickering Matthew C, van der Ende Arie, Kuijpers Taco W, Brouwer Matthijs C, van de Beek Diederik

Abstract excerpt

BACKGROUND: The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement factor H (FH) is a complement regulatory protein inhibiting alternative pathway activation but is also exploited by the pneumococcus to prevent complement activation on its...

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Identifiers

PMID: 31883521
DOI: 10.1186/s12974-019-1675-1
PMCID: PMC6935240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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