Article
Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis.
The Journal of clinical investigation - 1 Oct 2011
Woehrl Bianca, Brouwer Matthijs C, Murr Carmen, Heckenberg Sebastiaan G B, Baas Frank, Pfister Hans W, Zwinderman Aeilko H, Morgan B Paul, Barnum Scott R, van der Ende Arie, Koedel Uwe, van de Beek Diederik
Abstract excerpt
Pneumococcal meningitis is the most common and severe form of bacterial meningitis. Fatality rates are substantial, and long-term sequelae develop in about half of survivors. Disease outcome has been related to the severity of the proinflammatory response in the subarachnoid space. The complement system, which mediates key inflammatory processes, has been implicated as a modulator of pneumococcal meningitis...
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