Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.

doi:10.1007/s00401-013-1216-4

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Article

Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.

Acta neuropathologica - 1 Apr 2014

Brouwer Matthijs C, Meijers Joost C M, Baas Frank, van der Ende Arie, Pfister Hans-Walter, Giese Armin, van de Beek Diederik, Koedel Uwe

Abstract excerpt

Cerebrovascular complications are common in pneumococcal meningitis and are a main determinant of unfavourable outcome and death. We hypothesized that plasminogen activator inhibitor-1 (PAI-1) is a major contributor to cerebrovascular complications and death in pneumococcal meningitis. In a nationwide prospective cohort study we evaluated the effect of the 4G/5G polymorphism (rs1799889) in SERPINE1 (coding for...

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PMID: 24248324
DOI: 10.1007/s00401-013-1216-4

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SERPINE1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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